Home > News > Advanced functional materials: magnetic controlled photosynthetic Spirulina micro nano robot in situ oxygen production for tumor radiotherapy photodynamic therapy

Advanced functional materials: magnetic controlled photosynthetic Spirulina micro nano robot in situ oxygen production for tumor radiotherapy photodynamic therapy

wallpapers News 2020-09-14

with the continuous progress of micro nano technology robotics micro nano robots gradually come to people's vision. Micro nano robot is a kind of robot whose scale is between micro nano level can operate micro nano space precisely. Because of its flexible movement precise targeting drug delivery other capabilities it has broad application prospects in biomedical fields such as disease diagnosis treatment targeted delivery non-invasive surgery so on. However at this stage most of the researches on micro nano robots focus on in vitro it is still a great challenge to achieve more expected functions in vivo. In view of this the Zhou Min research group of the Second Affiliated Hospital of Zhejiang University the Institute of translational medicine of the Zhejiang University has used a hybrid microbiological swimming robot which uses the microalgae as living scaffolds "wear" magnetic coating coat target the delivery to tumor tissues successfully improve the hypoxic microenvironment of tumors effectively realize the guidance of three mode medical imaging of magnetic resonance / fluorescence / photoacoustic imaging. Tumor diagnosis treatment. The microenvironment of

tumor tissue especially the hypoxia microenvironment in tumor tissue is one of the important reasons for the tolerance of many tumor treatment methods. Especially in the commonly used clinical radiotherapy oxygen is involved in the damage of DNA double helix structure induced by ionizing radiation which promotes cell apoptosis. Hypoxia will affect the effect of radiotherapy lead to the tolerance of tumor cells. Therefore how to effectively reduce or reverse the hypoxic state of tumor is the key research content to enhance the effect of radiotherapy. Zhoumin research group of Zhejiang University synthesized a magnetically controlled photosynthesis micro nano robot through magnetic modification of natural spirulina targeted delivery to tumor tissue. Through in situ photosynthesis to produce oxygen to regulate the tumor hypoxic environment then use the chlorophyll release in Spirulina after radiotherapy to achieve multimodal medical image-guided tumor radiotherapy photodynamic therapy. In this paper we have designed a "nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructured nanostructure. The hybrid system maintained the high oxygen production activity of microalgae the directional magnetic drive ability of Fe3O4 nanoparticles. Under the control of external magnetic field magnetically engineered PBNs can target accumulate to the tumor produce oxygen in situ through photosynthesis to reduce the degree of hypoxia in the tumor so as to improve the efficiency of radiotherapy (RT). At the same time the chlorophyll released by PBNs after irradiation can be used as photosensitizer to produce cytotoxic reactive oxygen species (ROS) under laser irradiation which can realize the cooperative photodynamic therapy (PDT). In the mouse model of breast cancer in situ the enhanced combination therapy showed significant tumor growth inhibition. In addition PBNs not only have excellent T2 mode magnetic resonance imaging (MRI) function brought by Fe3O4 coating but also have chlorophyll based natural fluorescence (fli) photoacoustic imaging (PAI) functions which can noninvasively monitor tumor treatment tumor microenvironment changes. More importantly the nature of the micro nano swimming body as a natural organism can be effectively degraded in vivo which provides a transformation prospect for the application of biological hybrid materials in targeted delivery in vivo biomedicine.


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