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View: application of magnetic iron oxide nanomaterials in cancer diagnosis and treatment

wallpapers News 2020-12-28

with the continuous growth of population the aggravation of aging cancer is still one of the important factors threatening human health. In the past few decades the development of nanotechnology has greatly promoted the progress of cancer diagnosis treatment technology resulting in the birth of a series of nano drugs with excellent performance. Among them magnetic iron oxide nanomaterials (mions) play an important role in cancer nanomedicine due to their good biocompatibility unique physical chemical properties biological effects.

are based on the latest progress of mions in cancer nanomedicine. Professor Dong Xiaochen's team of Nanjing University of technology Professor Yang mengsu's team of City University of Hong Kong summarized discussed the controllable preparation biomedical application of magnetic iron oxide nanodrugs in recent years combined with the exploration experience of the laboratory in the field of nanodrug preparation cancer diagnosis treatment. In this paper based on the magnetic properties of mions the preparation methods performance control surface modification techniques of mions are summarized the applications of mions in the following aspects are further introduced: (1) magnetic resonance imaging. By adjusting the size morphology of mions or element doping the contrast of MRI can be improved the traditional MRI can be rejuvenated. (2) Magnetic particle imaging. Compared with the traditional imaging mode magnetic particle imaging as a new imaging technology based on nano materials has the advantages of high sensitivity high spatial-temporal resolution three-dimensional imaging quantitative data acquisition no ionizing radiation hazard. In addition superparamagnetic mions mediated magnetic particle imaging is expected to help researchers clinicians underst the course of cancer from organ cell even molecular level. (3) Magnetocaloric therapy. The magnetocaloric effect of mions in medium high frequency alternating magnetic field can effectively inhibit the further deterioration of tumor its magnetocaloric efficiency can also be regulated by changing the size anisotropy surface properties of materials. Compared with other hyperthermia methods magnetic hyperthermia is not limited by the depth of tissue penetration can be combined with magnetic imaging technology for real-time monitoring of nano drugs. (4) Magnetic targeted therapy. Using the response of mions to static magnetic field the distribution of mions in vivo is controlled by external magnetic field which can improve the tumor targeting efficiency of nanodrugs reduce the damage to normal tissues. In addition this paper summarizes the current clinical trials related to mions discusses the opportunities challenges in the development application of drugs based on mions provides a reference for the development of nanodrugs in the future.

original link: https://onlinelibrary.wiley.com/doi/10.1002/VIW.20200046


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